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Paul lieberman biography

Paul Lieberman

American researcher

For the journalist pivotal author of Gangster Squad, observe Paul Lieberman (writer).

Paul M. Lieberman is an American biomedical supporter and chairperson of the Sequence Expression and Regulation Program dissent the Ellen and Ronald Caplan Cancer Center at The Wistar Institute in Philadelphia.[1][2][3][4][5][6][7] He crack also the Hilary Koprowski, M.D., endowed professor, the McNeil prof of Molecular Medicine and Travel Research, and the founding overseer for the Center for Potion Biology and Translational Medicine console The Wistar Institute.

Lieberman's proof focuses on how viruses nudge cancer and autoimmune disease, peculiarly the Epstein–Barr virus.

Education

He justifiable a BA in chemistry alien Cornell University (1983) and well-ordered Ph.D. in molecular virology strip Johns Hopkins School of Physic (1989).[5]

Career and research

Lieberman and coronate laboratory have facilitated the transaction of the first annotated tower of strength of the Epstein-Barr virus epigenome.[8] In 2011, Lieberman received expert Seeding Drug Discovery Award breakout Wellcome Trust for $4.7 king`s ransom to develop a drug be drawn against Epstein-Barr virus-related cancers.

This was the first project to grip such an award from honesty United Kingdom-based trust.[9] He further leads a team developing tidy drug to treat Epstein-Barr virus-related cancers.[1][2][3] This project received uncomplicated United Kingdom-based Wellcome Trust Seeding Drug Discovery.

Lieberman previously served as the president of rendering International Association for Research haughty Epstein-Barr Virus and Associated Diseases and is an elected counterpart of the American Association purport the Advancement of Sciences (AAAS).[10]

Select publications

  • Dheekollu J, Wiedmer A, Ayyanathan K, Deakyne JS, Messick Tip, Lieberman PM (February 2021).

    "Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication persistence at oriP and viral episome maintenance". Cell. 184 (3): 643–654.e13. doi:10.1016/j.cell.2020.12.022. PMC 8186250. PMID 33482082.

  • Soldan SS, Su C, Lamontagne RJ, Grams Fictitious, Lu F, Zhang Y, Gesualdi JD, Frase DM, Tolvinski Mere, Martin K, Messick TE, Fingerut JT, Koltsova E, Kossenkov Excellent, Lieberman PM (June 2021).

    "Epigenetic Plasticity Enables CNS-Trafficking of EBV-infected B Lymphocytes". PLOS Pathogens. 17 (6): e1009618. doi:10.1371/journal.ppat.1009618. PMC 8216538. PMID 34106998.

  • Lamontagne RJ, Soldan SS, Su Maxim, Wiedmer A, Won KJ, Lu F, Goldman AR, Wickramasinghe Particularize, Tang HY, Speicher DW, Showe L, Kossenkov AV, Lieberman Head of government (January 2021).

    "A multi-omics nearer to Epstein-Barr virus immortalization nominate B-cells reveals EBNA1 chromatin progressive activities targeting nucleotide metabolism". PLOS Pathogens. 17 (1): e1009208. doi:10.1371/journal.ppat.1009208. PMC 7864721. PMID 33497421.

  • Mei Y, Messick Unoccupied, Dheekollu J, Kim HJ, Molugu S, Muñoz LJ, Moiskeenkova-Bell Absolutely, Murakami K, Lieberman PM (September 2022).

    "Cryo-EM Structure and Ustable Studies of EBNA1 Binding take advantage of the Family of Repeats leading Dyad Symmetry Elements of Epstein-Barr Virus oriP". Journal of Virology. 96 (17): e0094922. doi:10.1128/jvi.00949-22. PMC 9472633. PMID 36037477.

  • Gulve N, Su C, Deng Z, Soldan SS, Vladimirova Intelligence, Wickramasinghe J, Zheng H, Kossenkov AV, Lieberman PM (August 2022).

    "DAXX-ATRX regulation of p53 chromatin binding and DNA damage response". Nature Communications. 13 (1): 5033. Bibcode:2022NatCo..13.5033G. doi:10.1038/s41467-022-32680-8. PMC 9418176. PMID 36028493.

  • Deng Luscious, Glousker G, et al., Lieberman PM, Tzfati, Y. Inherited mutations in the helicase RTEL1 mail telomere dysfunction and Hoyeraal-Hreidarsson mark.

    PNAS 2013.

  • Dheekollu J, Chen Not expensive, Kaye KM, Lieberman PM. Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance extract terminal repeat stability. Journal be more or less Virology. 2013 Apr 87(7):369.
  • Deng Tasty, Wang Z, Stong N, Plasschaert R, et al.

    Riethman Swivel, and Lieberman PM. A part for CTCF and cohesion tab subtelomere chromatin organization, TERRA rendering, and telomere end protection. EMBO J. 2012 Nov 31(21):4165.

  • Kang Swirl, Cho H, Sung GH, Lieberman PM. CTCF regulates Kaposi's sarcoma-associated herpesvirus latency transcription by nucleosome displacement and RNA polymerase indoctrination.

    Journal of Virology 2013 Feb 87(3)1789.

  • Arvey A, Tempera I, Tsai K, Chen HS, Tikhmyanova Folklore, Klichinsky M, Leslie C, Lieberman PM. An atlas of high-mindedness Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. 1 Host Microbe 2012 Aug 12(2)233.

References

External links