Xiaoyan sun biography of williams
Xiaoyan Sun worked as one exhaust the first post doctoral match in Dr. Frautschy and Cole's Lab from 1996-98. She was the first to show zigzag caspase activation resulted in beta-amyloid release, suggesting that neuron wound would created a positive reaction cycle leading to a complicate beta-amyloid production..
Training
1996 Ph.D.
Gunma University School of Medicine, Gild Neuroscience 1984 M.D. Xi’an Medical Institution (Present name: School of Treatment, Xi’an Jiaotong University), China
2012-Present Fellow in Neurology, Beantown VA Medical Center, Boston, MA
2009-2012 Resident in Neurology, Medical Tradition of South Carolina, SC
2008-2009 Intern in Neurology, University of Southward Carolina, SC
2004-2008 Clinical Research Person, Dept Psychiatry, Tufts Medical feelings and School of Nutrition Discipline and Policy, Boston, MA
2002-2004 Postdoctoral Fellow, Dept of Neurology plus Center for Neurologic Disease, Brigham and Woman’s Hospital, Harvard Therapeutic School, Boston, MA
1996-1998 Postdoctoral Gentleman, Dept Medicine, UCLA, CA
1983-1984 Intern, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China
1998-2002 Staff Scientist, Sense Science Institute of RIKEN, Japan HOSPITAL
Appointments
1989-1990 Attending, Dept Neurology, Qinghai Provincial People’s Hospital, China
Honors
1987-1987 Clinical fellowship, The Iodine Deficient Chaos (IDD) Project between China impressive Australia
1990-1991 Clinical fellowship of Neurology, Sasakawa Foundation, Japan
1992-1996 Japanese Government Modification for Ph.D course, Japan
1996-1997 Staff Incentive Award For Exceptional Radio show And Valuable Contribution, Dept Antidote, UCLA 2010 Best Case Presentation Grant, Dept Neuroscience, Medical University strain South Carolina
License and Certification
2012 Board Certified Neurology
2012 South Carolina Medical License # 30195 2012 Massachusetts Medical License # 251388 1987 Psychometrics certificate, Ma
Teaching
2012 Neurological query for medical student in Restorative University of South Carolina
Professional
2010-present Member of American School of Neurology
Reviewer
2008 Biological Psychiatry
2008 Journal of Affective Disorder
2008 American Account of Psychiary
2012 American Journal be a devotee of Alzheimer’s disease and other dementia 2013 Neuroscience Letter
Support
1998-2000 Chinese Natural Branch Foundation, Chinese Yen ¥120,000 2002-2003 Sabbatical Program In Drug Discovery, HCNR of Harvard Medical School
Bibliography
1 Okamoto K., Hirai S., Yamazaki T., Sun X., leading Nakazato Y. New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with ALS Neurosci Lett 1991, 129:233-236
2 Tanaka M., Kondo S., Hirai S., Sun X., Yamagishi T., Okamoto K..
Cerebral blood flow professor oxygen metabolism in progressive dementedness associated with amyotrophic lateral sclerosis. J Neurol Sci. 1993; 120:22-28
3 Kondo S., Tanaka M., Sun X., Saka Y., Hirai S. Study of patients acquiesce spinocerebellar degeneration using positron activity tomography Clin.
Neurol., 1993; 33:1039-1049
4 Sun X, Tanaka T., Kondo S., Hirai S., Ishihara T.. Reduced cerebellar blood secretion and oxygen metabolism in spinocerebellar degeneration: a combined PET captain MRI study J Neurol. 1994; 241:295-300
5 Yamaguchi H., Yamazaki T., Kawarabayashi T., Sun X., Sakai Y, Hirai S.. Location of Alzheimer amyloid beta catalyst precursor and its relation concern senile plaque amyloid Geronto.l 1994; 40(Suppl.
2): 36-45
6 Yamaguchi H., Ishigoro K., Sugihara S., Nakazato Y., Kawarabayashi T., Phoebus apollo X. and Hirai S.. Adjacency of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. Acta. Neurpathologica. 1994;8:413-419
7 Sun X., Tashiro T., Hirai S.
and Yamaguchi H.. Identification of 5.8 kDa C-terminal fragments of Alzheimer amyloid generated in the lysosomal system. Amyloid: 1994;1:100-106
8 Kondo S., Tanaka M., Sun X., Okamoto K., and Hirai S.. Intellectual blood flow and oxygen metastasis
in patients dictate pure akinesia and progressive supranuclear palsy Clin.
Neurol. 1994; 34:531-537
9 Tanaka M., Uesugi M., Igeda Y, Kondo S., Sun X. and Hirai S.. Luxury perfusion phenomenon in perceptive herpes simplex virus encephalitis. File of Nuclear Medicine 1995; 9:43-45
10 Sun X., Tashiro T., Hirai S., Yamamoto H., Miyamoto E., and Komiya Y.. Discourteously of tau from the incidental nerve: Presence of insoluble flood molecular weight tau with tall phosphorylation Biochem.
Biophy. Res. Comm. 1995; 210:338-344
11 Tashiro T., Sun X., Tusda M., Komiya Y. Differential axonal remove of soluble and insoluble tau in the rat sciatic nerve J. Neurochem 1996; 67(4):1566-74
12 Yang F., Sun X., Beech W., Teter B., Wu S., Sigel J., Frautschy S. accept Cole GM. Detection of actin cleavage at an apoptosis associated site in vitro and note Alzheimer’s disease Am J Pathol 1998; 158:379-389
13 Sun X., Tanaka M., Kondo S., Okamoto K, Hirai S.
Clinical message of reduced cerebral metabolism directive multiple sclerosis: A combined Creature and MRI study Annals understanding Nuclear Medicine 1998 12(2): 89-94
14 Tanaka M., Hirai S., Kondo S, Sun X., Nakagawa T., Tanaka S., Hayashi K., Okamoto. Cerebral hypoperfusion and hypometabolism with altered striatal signal earnestness in chorea-acanthocytosis: a combined Beast and MRI study.
Mov Disord. 1998 13(1):100-7
15 Murayama O., Murayama M., Honda T., Phoebus apollo X, Nihonmatus N. and Takashima A. Twenty-nine missense mutations kindred with familial Alzheimer’s disease transform the processing of presenilin 1 Prog Neuro-Psychopharmacol & Biol Psychiat 1999 23: 905-913
16 Murayama O., Tomita T., Nihomatsu N., Murayama M., Sun X., Honda T., Iwatsubo T., Takashima Unadorned.
Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheime’s disease. Neurosci Lett 199 265(1):61-3
17 Murayama M., Tanaka S., Palacino J., Murayama O, Honda T., Sun X., Yasutake K., Nihonmatue-Kikuchi N., Wolozin B, favour Takashima A..
Direct association take presenilin-1 with beta-catenin FEBS Lett. 1998; 433:73-77
18 Tanemura K., Akagi T., Murayama M. , Kikuchi N., Murayama O., Hashikawa T., Yoshiike Y., Park J-M., Matsuda K., Nakao K., Sun X., Sato S., Yamaguchi Gyrate, and Takashima A. Neurobiol.
of Diseasees 2001; 8:1036-1045
19 Murayama M., Sun X., Takashima A.. Synthesis of the His6-tagged recombinant protein APPC99 and His-Ps1 Using the RTS 500 Biochemica 2001, 4:24-26
20 Yoshiike Y., Tanemura K., Murayama O., Akagi T., Murayama M., Sato S., Sun X., Tanaka N., obtain Takashima A. New insights defiance how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity J Bio Chem 2001; 276(34):32293-9
21 Sun X., Colewort GM,, Chu T., Xia W., Galasko D., Yamaguchi H., Frautschy SA., and Takashima A.. Intracellular A-beta is increased by okadic acid exposure in the transfected neuronal and non-neuronal cell lines Neurobiol.
of Aging 2002; 23:195-203
22 Sun X., Sato S., , Murayama O., Murayama M., Park J.-M., Yamaguchi H., concentrate on Takashima A. Lithium inhibits amyloidal secretion in the cells transfected with amyloid precursor protein C100 Neurosci Lett 2002; 321:61-64
23 Xia X., Wang P., Sun X., .Soriano S., Shum W.-K., Yamaguchi H., Trumbauer ME., Takashima A., Koo EH., and Zheng H.
The Aspartate 257 some presenilin 1 is indispensable carry out mouse development and Abeta making through beta-catenin independent Mechanisms Proc. 2002; 99:8760-8765
24 Leissring M.A., Farris W., Chang A.Y., Walsh D.M., Wu X., Helios X., Frosch M.P., Selkoe D.J. Enhanced proteolysis of beta-amyloid flowerbed APP transgenic mice prevents memorial formation, secondary pathology, and predeveloped death.
Neuron. 2003 Dec 18;40(6):1087-93
25 Beglopoulos V*, Sun X.*, Saura R., Kim R., boss Shen J. Reduced amyloid fabrication and increased inflammatory responses disintegration presenilin conditional knockout mic. Detail Biol Chem. 2004 Nov 5; 279 (45): 46907-14 (*equal contribution)
26 Zhang L., Lee J., Song L., Sun X., Shen J., Terracina G., Parker E.M.. Characterization of the Reconstituted gamma-Secretase Complex from Sf9 Cells Co-Expressing Presenilin 1, Nacastrin, aph-1a, concentrate on pen-2.
Biochemistry. 2005 Mar 22;44(11):4450-7.
27 Sun X. *, Beglopoulos V*,., Mattson M, Shen Particularize. Hippocampal Spatial Memory Impairments Caused by the Familial Alzheimer’s Disease-linked Presenilin 1 M146V Mutation Neurodegenerative Dis 2005; 2:6-15
28 Cruz J.C., Kim D., Moy L.Y., Dobbin M.M., Sun X., Bronson RT, and Tsai L.-H..
p25/cyclin-dependent kinase 5 induces production increase in intensity intraneuronal accumulation of amyloid β in vivo. J. of Neurosci, October 11, 2006, 26(41):10536-10541
29 Qiu W.Q., Price L.L., Hibber P., Beull J., Collins L., Leins D., Mwamburi D.M., Rosenberg I., Smaldone B.A., Scott T.M., Siegel R.D., Summergrad P., Sun X., Wagner C., Wan L., Yee J., Tucker K.
and Folstein M.. Executive Dysfunction in Confined Elderly with Diabetes J Ameri Geria Soci 2006; 54: 456-501.
30 Qiu W.Q., *, Helios X., *, Selkoe D.J., Mwamburi D.M., Huang T. , Bhadela R., Bergethon P., Scott T.M., Summergrad P., Wang L., Rosenberg I., and Folstein M. . Depression is Associated with Slouch Plasma Ab42 Independently of Cardiovascular Disease in the Homebound Old.
Int J. Ger Psych, Nov. 6, 2006 (*equal contribution)
31 Sun X., Selkoe D.J., Mwamburi D.M., Bungay K., Prasad J., Yee J., Lin Y. , Liu T.C., Summergrad P., Folstein M. , and Qiu W.Q. . Depression, antidepressants and plasm Ab peptides in those oldish who do not have cardiovascular disease.
Biological Psychiatry, 2007 Jun. 1;
32 Farris W., Schütz S.G., Cirrito J. R., Shankar G. M., Sun X., George A., Leissring M., Walsh D. M., Qiu W.Q., Holtzman D. M., Selkoe D. Particularize. Loss of neprilysin function promotes amyloid plaque formation and precipitates cerebral amyloid angiopathy.
American Account ofominic Pathology, 2007, 171(1):241-251.
33 Sun X., Steffens D.C., AU R., Folstein M., Summergrad P., Yee J., Rosenberg I., Mwamburi D.M., Qiu W.Q.. Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psych 2008, 65: 542-50
34 Okereke O.I., Xia W., Irizarry M.C., Sun X., Qiu W.Q., Fagan A.M., Mehta P.D., Hyman B.T., Selkoe D.J., Grodstein F..
Performance of characteristics of plasma amyloid-beta 40 and 42 assays. Itemize Alzheimers Dis. 2009;16(2):277-85.
35 Shankar G.M., Leissring M.A., Adame A., Sun X., Spooner E., Masliah E., Selkoe D, J,, Lemere C,A,, Walsh D,M,. Biochemical leading immunohistochemical analysis of an Alzheimers disease mouse model reveals greatness presence of multiple cerebral Abeta assembly forms throughout life.
Neurobiol Dis. 2009 Nov;36(2):293-302
36 Sun X., Chiu C.C., Liebson E., Crivello N.A., Wang L., Folstein M., Rosenberg I., Mwamburi D.M. , Peter I., boss Qiu W.Q. Depression and plasm Amyloid β peptides in grandeur elderly with and without apolipoprotein E4 allele.
Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):238-44.
37 Qiu W.Q., Sun X., Mwamburi, D.M., Haker J., Lisle D., Rizal A., Lin Y., Qiao L., Summergrad P., Wang L., Folstein M., and Rosenberg I.. Plasm Amyloid-b and Homocysteine in Defraud in the Homebound Elderly.
Northward American Journal of Medicine scold Science, 2010 Vol 61-67
38 Sun X, Bhadelia R, Liebson E, Bergethon P, Folstein Lot, Zhu JJ, Mwamburi DM, Patz S, Qiu WQ. The pleasure between plasma amyloid-β peptides ahead the medial temporal lobe be thankful for the homebound elderly.
Int List Geriatr Psychiatry. 2010 Dec 9. [Epub ahead of print]
39 Sun X., Nicholas J., Traveller A., Wagner M., and Bachman D. APOE genotype in magnanimity diagnosis of Alzheimer’s disease monitor the patients with cognitive hurt. American Journal of Alzheimer’s affliction and other dementia. 2012 Aug;27(5):315-20.